Research Articles
E. coli vs. S. cerevisiae: Choosing the Optimal Metabolic Engineering Host
Selecting the right microbial host is a critical first step in developing efficient cell factories for the production of fuels, chemicals, and pharmaceuticals.
Beyond Stoichiometry: How Enzyme-Constrained Metabolic Models Are Revolutionizing Phenotype Prediction in Biomedicine
This article explores the transformative impact of enzyme-constrained metabolic models (ecModels) compared to traditional genome-scale metabolic models (GEMs).
Unlocking Cellular Factories: A Guide to Metabolic Flux Analysis for Identifying Pathway Bottlenecks
This article provides a comprehensive guide for researchers and drug development professionals on using Metabolic Flux Analysis (MFA) to identify critical bottlenecks in metabolic pathways.
Advanced Strategies for Enhancing Microbial Strain Tolerance: From Cell Engineering to AI-Driven Discovery
This article provides a comprehensive overview of cutting-edge strategies to enhance microbial tolerance, a critical bottleneck in industrial biomanufacturing and antibiotic development.
Strategic Balance: Navigating Growth-Product Formation Trade-Offs in Pharmaceutical Development
This article provides a comprehensive analysis of the critical trade-offs between cellular growth and product formation in pharmaceutical development, a central challenge impacting the success and efficiency of biomanufacturing.
Overcoming Techno-Economic Hurdles: A Strategic Framework for Scaling Advanced Technologies from Lab to Market
This article provides a comprehensive framework for researchers, scientists, and drug development professionals navigating the complex techno-economic challenges of commercial scaling.
Combating Over-Oxidation in Alkane Conversion: Advanced Strategies for Selective Catalysis and Microbial Engineering
Over-oxidation to undesired carbon oxides (COx) remains a fundamental challenge that limits the efficiency and economic viability of alkane conversion processes for producing valuable chemicals and biofuels.
Optimizing Enzyme Catalytic Efficiency with k-OptForce: A Computational Framework for Strain Design and Drug Development
This article explores k-OptForce, a computational framework that integrates kinetic modeling with stoichiometric Flux Balance Analysis (FBA) to optimize enzyme catalytic efficiency for metabolic engineering and drug development.
Strategies for Reducing Metabolic Burden in Engineered Strains: From Foundational Concepts to Industrial Applications
This comprehensive review addresses the critical challenge of metabolic burden in engineered microbial strains, a pervasive issue limiting productivity in industrial biotechnology.
Overcoming Biomass Recalcitrance: Advanced Strategies for Efficient Biofuel Production
The inherent recalcitrance of lignocellulosic biomass presents a fundamental barrier to the cost-effective production of second-generation biofuels.