Research Articles
Beyond the Obvious: Advanced Strategies for Identifying Non-Intuitive Metabolic Engineering Targets
This article provides a comprehensive guide for researchers and scientists on systematic approaches to uncover nonobvious genetic targets for metabolic engineering, moving beyond traditional, intuition-based methods.
Screening by Proxy: The High-Throughput Solution for Modern Metabolic Engineering
This article explores 'screening by proxy,' a pivotal strategy in metabolic engineering that addresses a central bottleneck: the lack of high-throughput assays for most industrially relevant molecules.
Accelerating Biomanufacturing: A High-Throughput Screening Workflow for Metabolic Engineering Strain Development
This article provides a comprehensive guide for researchers and scientists on implementing high-throughput screening (HTS) workflows to overcome the central challenge in metabolic engineering: the inability to rationally design high-performing...
Comprehensive Evaluation of Microbial Cell Factories: Strategies for Optimizing Bioproduction in Biomedicine
This article provides a systematic analysis of microbial cell factory capacities, a cornerstone of sustainable biomanufacturing for pharmaceuticals and chemicals.
Beyond E. coli: A Systematic Framework for Comparing Genetic Circuit Behavior Across Bacterial Species
This article provides a comprehensive framework for researchers and drug development professionals to understand, design, and optimize genetic circuits for reliable function across diverse bacterial hosts.
Beyond the Basics: A Modern Guide to Titer, Yield, and Productivity for Microbial Cell Factory Evaluation
This article provides a comprehensive framework for researchers, scientists, and drug development professionals to evaluate and optimize microbial cell factories.
Host-Specific Superiority in Chemical Production: Engineering Bio-Advantages for Next-Generation Therapeutics
This article explores the critical concept of host-specific superiority in the production of complex chemicals, with a focus on biomedical applications.
Comparative Analysis of E. coli, S. cerevisiae, B. subtilis, C. glutamicum, and P. putida for Biomanufacturing and Drug Development
This article provides a comprehensive comparison of five pivotal microbial hosts—Escherichia coli, Saccharomyces cerevisiae, Bacillus subtilis, Corynebacterium glutamicum, and Pseudomonas putida—targeted at researchers, scientists, and drug development professionals.
Benchmarking Microbial Chassis for Polyketide Production: A 2025 Guide for Synthetic Biology and Drug Discovery
The efficient heterologous production of polyketides is pivotal for drug discovery and development, yet the selection and optimization of a chassis strain remain significant challenges.
Bridging the Gap: From Maximum Theoretical Yield to Achievable Yield in Drug Development
This article provides a comprehensive framework for researchers, scientists, and drug development professionals to understand, calculate, and optimize the critical transition from maximum theoretical yield to achievable yield.