Research Articles
Beyond the Active Site: Innovative Strategies to Enhance Rate-Limiting Enzyme Catalytic Efficiency
This article provides a comprehensive overview of contemporary strategies for enhancing the catalytic efficiency of rate-limiting enzymes, a critical focus for researchers and drug development professionals.
Overcoming Protein Constraints in Heterologous Production: A Strategic Guide for Researchers
Heterologous protein production is a cornerstone of modern biotechnology and biopharmaceuticals, yet researchers consistently face constraints that limit yields and protein functionality.
Multi-Gene Stacking Strategies in Synthetic Biology: Engineering Complex Traits for Next-Generation Therapeutics
This article provides a comprehensive analysis of multi-gene stacking strategies, a cornerstone technology in synthetic biology for engineering complex polygenic traits.
Metabolic Engineering for Alkane to Diol Bioconversion: Pathways, Hosts, and Future Bioproduction
This article explores the cutting-edge metabolic engineering strategies enabling the microbial conversion of alkanes into valuable diols, key building blocks for polymers and pharmaceuticals.
Genome-Scale Metabolic Models: A Strategic Framework for Advanced Strain Design and Therapeutic Discovery
Genome-scale metabolic models (GEMs) represent powerful computational platforms that bridge genotype to phenotype, enabling the prediction of cellular metabolic behavior.
Engineering Plant Metabolic Pathways for Nutrition: From Biofortification to Smart Crops
This article synthesizes current strategies and future directions in plant metabolic engineering for enhancing nutritional quality, tailored for researchers, scientists, and drug development professionals.
Strategies for Heterologous Pathway Reconstruction in Yeast: From Foundational Concepts to Advanced Biomedical Applications
This article provides a comprehensive overview of heterologous pathway reconstruction in yeast, a cornerstone of modern metabolic engineering for drug development and sustainable biomanufacturing.
Metabolic Engineering of Yarrowia lipolytica for High-Yield Diol Production: Pathways, CRISPR Tools, and Industrial Applications
This article provides a comprehensive analysis of advanced metabolic engineering strategies for producing diols using the oleaginous yeast Yarrowia lipolytica.
Engineering Saccharomyces cerevisiae: Metabolic Pathways for Sustainable Chemical Production
This article provides a comprehensive overview of the metabolic engineering of the yeast Saccharomyces cerevisiae for the sustainable production of high-value chemicals.
ecFactory: A Computational Pipeline for Predicting Metabolic Engineering Gene Targets
This article provides a comprehensive overview of the ecFactory computational pipeline, a method designed for the systematic prediction of gene targets in metabolic engineering.